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Pharmaceutical Roller Compactor Dry Granulation For Western Medicine

제품 세부 정보

원래 장소: 창주

브랜드 이름: Shengman

인증: CE

모델 번호: 엘지

지불 및 배송 조건

최소 주문 수량: 1세트

가격: USD30,000-300,000

포장 세부 사항: 내보내기 패키지

배달 시간: 30-90일

지불 조건: 티/티

공급 능력: 1-10sets/월

최고의 가격을 얻으십시오

제품 세부 정보

제품 설명

강조하다:

용량:	고객이 요구하는	선택 기기:	마이크로 피더 장치
공급자:	중국 공장	제어 시스템:	PLC
부분품:	유명 브랜드	먹이는 유형:	수평공급형
특징:	물과 용제 없음	보증:	1년
재료:	SS304, 316L	핵심 판매 지점:	유명 브랜드 PLC
해당 산업:	제약, 화학, 식품 산업

용량:	고객이 요구하는
선택 기기:	마이크로 피더 장치
공급자:	중국 공장
제어 시스템:	PLC
부분품:	유명 브랜드
먹이는 유형:	수평공급형
특징:	물과 용제 없음
보증:	1년
재료:	SS304, 316L
핵심 판매 지점:	유명 브랜드 PLC
해당 산업:	제약, 화학, 식품 산업

Pharmaceutical Roller Compactor Dry Granulation For Western Medicine

The application of Roller Compactor (dry granulation machine) in the production of western medicine (chemical drugs, biopharmaceuticals, etc.) is very mature and extensive, and it is one of its most classic and core application fields. With the deepening of continuous manufacturing and QbD concept, the importance of roller compactor in the field of Western medicine intelligent manufacturing will be further enhanced due to its easy control of parameters and integration.

Many active ingredients (APIs) in Western medicine have the following characteristics:

Sensitive to moisture and heat: Many APIs are unstable when exposed to water or heat, and are prone to hydrolysis, oxidation, or crystal transformation.

Low dose: The API content in the prescription is very low (such as less than 1%), and it needs to be evenly mixed with a large amount of excipients. Wet granulation may cause uneven content.

Insolubility: About 70% of modern new drugs are insoluble, and wet granulation may exacerbate their dissolution problems, while dry granulation does not affect their inherent dissolution characteristics.

Compliance requirements: Strictly avoid solvent residue and comply with international regulatory guidelines such as ICH.

The Roll Compactor can perfectly solve these inherent problems of Western medicine API, so roller compactor is the preferred process and equipment for Western medicine granulation production.

Pharmaceutical Roller Compactor Dry Granulation For Western Medicine 0

Model	LG100	LG100E	LG160	LG200	LG240	LG360
Capacity (kg/h)	1.5-15	12-40	50-150	100-240	160-320	360-720
Rated power (kw)	3.47	3.53	7.24	11.37	15.94	32.55
Roller size (D*W)	100*25	100*40	160*50	200*75	240*100	360*150

For large production scale application, we provide double-supporting roller model

Model	LGS200	LGS240	LGS360	LGS500
Capacity (kg/h)	200-400	300-640	1200-2000	1500-3000
Rated power (kw)
Roller size (D*W)

Main application scenarios and functions of dry granulation machine

1. As a pretreatment for direct tablet pressing (most commonly used)

Scenario: When the mixture of API and excipients has poor fluidity, insufficient compressibility, or there is a risk of separation, it cannot be directly pressed into tablets.

Function: Dry Granulator is used to make granules with excellent fluidity and compressibility, while ensuring that the mixing uniformity is not disrupted. This is an effective supplement to the direct compression process.

2. Handling highly active or harmful substances

Scenario: Production of highly effective drugs such as cytotoxic drugs and hormones.

Function: The entire dry granulation process is carried out in a fully enclosed system, greatly reducing the risk of operators being exposed to hazardous dust and ensuring production safety.

3. Production of water sensitive materials

Scenario: Production of easily hydrolyzed materials (such as aspirin, certain antibiotics, proton pump inhibitors, etc.).

Function: Completely avoid the use of water or organic solvents, fundamentally eliminate the risk of hydrolysis, and ensure the chemical stability of the product.

4. Improve materials dissolution behavior (under specific circumstances)

Scenario: For certain materials, the high-pressure rolling process may result in partial microcrystallization or crystal defects, which can actually increase the specific surface area and improve the dissolution rate.

Attention: This requires further research as pressure may also cause crystal transformation or have the opposite effect.

5. Production of special dosage forms such as effervescent tablets and chewable tablets

Scenario: The acid and base sources (such as citric acid and sodium bicarbonate) in effervescent tablets must not come into contact with water.

Function: Roller compactor is the only or best choice for producing intermediate particles in this type of dosage form, ensuring that all ingredients are absolutely dry before compression.

Pharmaceutical Roller Compactor Dry Granulation For Western Medicine 1

Why Choose Us:
We are a leading Chinese manufacturer specializing in dry granulation equipment. With extensive experience in custom engineering solutions, we ensure that each machine meets your unique production requirements, improving efficiency and product quality.

Call-to-Action:
Contact us today to discuss your production needs and get a customized dry granulation solution!

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Pharmaceutical Roller Compactor Dry Granulation For Western Medicine

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